Primary Characteristics
Autism results from a type of abnormal brain development. The main features of autism include poorly developed social interactions, difficulties with speech and communication, and repetitive and restrictive behaviors. Generally, these features are present before a child is 3-years-old.
Parents of autistic children often notice normal development at first, but then sudden regression. The regression in the development of autism is an expected aspect of the disorder.
Other Characteristics
While it isn’t always the case, autistic children usually have mild to severe cognitive impairments (developmental delays and mental retardation). They might also exhibit significant sensory symptoms, including eating disorders. Many children with autism suffer with heightened anxiety, with or without obsessive-compulsive behaviors (e.g., lining up toys in a strict row). Attention deficit hyperactivity disorder (ADHD) and learning problems are more prevalent in autistic kids than in the general population. Temper tantrums and moderate-to-severe behavioral problems (sometimes including the destruction of property) are common as well.
Other features may include:
- Poor eye contact and facial recognition
- Distress from loud noises
- Failure to point at things that should offer interest
- Finger, hand or arm flapping, especially when excited
- Repetitive or rocking behaviors
- Increased incidence of seizures with regressions in speech and other areas of development
- Insomnia
- Motor and vocal tics (signs of Tourette syndrome)
- Narrowly focused interests, sometimes with the ability to greatly excel in the specific area of interest (i.e., “savantism”)
Since the signs of autism are highly variable, these secondary features aren’t seen in all autistic individuals. However, when they are present, these characteristics frequently create challenges.
Social Development
The social problems experienced by autistic patients may begin quite early and progress with the child’s development. Poor eye contact and lack of facial recognition may show up in infancy. There may be perceived attachment difficulties. Children may fail to turn to things pointed out to them. A child may have severe tantrums and act aggressively toward others.
Recognition of social cues may not develop on time. For example, the autistic child may not understand the concept of taking turns or rules for games. Autistic kids may not share well with others, and often have trouble making and keeping friends. As they gain awareness of their differences, autistic children can become very lonely.
Communication Problems
Difficulties in speech and communication may also show up quite early. Autistic children may fail to recognize their own name by 10 months of age. There may be delays in babbling or gesturing (e.g., pointing or waving bye-bye) until after 12 months. Normal back and forth in vocalizations between parent and child may not be present. There may be no single words until after 16 months and no two-word phrases uttered independently until after 24 months. Delay in language development is a serious warning sign, as is the regression of language or social skills at any age.
Autistic children may repeat what others say without meaningful interaction. They may mix up pronouns, or talk nonstop and repetitively about an area of narrow interest without pause or meaningful two-way conversation. Typically, they don’t understand jokes or sarcasm. Autistic kids frequently just “don’t get” other people, leading to difficulties in making friends.
Repetitive Behaviors
The repetitive behaviors of autism may have many manifestations, such as rocking back and forth, or finger/hand/arm flapping.
Autistic children may strongly dislike change in routine, preferring ritual and sameness. They can be compulsive, lining toys up or drumming fingers or spoons. Sometimes autistic children injure themselves with behaviors like repetitive head banging or picking at their skin.
Sub-Types of Autism
Asperger’s syndrome is a sub-type of autism in which speech and cognitive (thinking) difficulties are not as severe. As a group, patients with Asperger’s are found to have a higher level of functioning. Pervasive developmental disorder (PDD) is a term reserved for children who have many of the features of autism, but who do not meet strict criteria.
Incidence
The incidence of all forms of autism combined in the U.S. is now observed to be about 1 in 110 children, representing a significant rise over the last few generations. This perceived increase in incidence might be due to better techniques for recognizing the disorder or factors not yet identified (or perhaps both of these reasons).
Causes
While the exact cause of autism is unknown, progress has been made in understanding its roots. Most likely, there isn’t a single cause, but rather, autism should be thought of as a final common pathway that is entered by a variety of means.
For example, it is likely autism has a strong genetic component (there is increased incidence within family units and in twins). With greater detail possible from gene mapping, an increasing number of autistic children have been shown to have one of a variety of genetic defects. Abnormalities in specific genes reveal deletions (a copy or copies of the gene are missing), duplications (there are extra copies of the gene on one or more chromosomes) and inversions (the gene is basically upside down on the chromosome). These defects can be found in autistic patients for an increasing number of genes.
Some toxins, including lead and other heavy metals, and ingestion of alcohol and certain seizure medications during pregnancy, have also been implicated as possible causes of autism. Fetal alcohol syndrome patients seem to share many behavioral features with autistic patients.
The theory that some vaccines or their preservatives cause autism has been thoroughly and completely ruled out. According to an article published in The Wall Street Journal in January 2011, the original research implicating vaccines as a cause of autism was fabricated by a British scientist who was subsequently stripped of his medical license. Many of the other original authors have withdrawn their names from the study and The Lancet (the medical journal where the study was published) has issued a formal retraction. The damage to the reputation of vaccines and the resulting public health problems are truly unfortunate.
An older theory that autism is caused by cold-hearted, unfeeling mothers has also been debunked. Parents of autistic children are typically kind, caring and concerned people who love their kids very much.
The Importance of Early Screening
On average, kids in the U.S. are officially diagnosed with autism at around 5 or 6-years-old. However, many autistic children are formally diagnosed even later. Because the earlier the diagnosis, the better the outcome, the American Academy of Pediatrics recommends an autistic screening for all children at their 18 and 24-month or 30-month physical examinations.
When autism is suspected, children should be tested with an age-appropriate screening tool (regardless of their age). Psychologists trained in diagnosing autism should complete extensive follow-up testing if screening tests show any signs of the disorder.
The Value of Treatment
Placing a child in an intensive special education program with personnel specially trained to teach autistic children is one of the most valuable and important treatment options. Special education programs may offer applied behavioral analysis (ABA), structured teaching in very small classroom settings, frequent and intensive speech therapy, occupational therapy, social skills classes, play therapy, and counseling. If the school doesn’t provide complete services
or is unable to offer services on a regular basis, parents might wish to consider evaluating a private center for autism (e.g., The Envision Center in Battle Creek).
Currently, there are only two medications approved by the U.S. Food and Drug Administration (FDA) to treat autism: Abilify and Risperdal. Both of these drugs are powerful anti-psychotic medications that have side effects. They are generally used in autistic children to help control aggression and severe behavioral problems. Abilify and Risperdal may stabilize mood, decrease anxiety and depression, alleviate motor and vocal tics, and improve sleep. As with all medications, your health care provider should help you weigh the risks and the benefits.
Other medications may sometimes be used in a targeted fashion to treat specific, associated conditions (called co-morbidities). For example, ADHD is treated with ADHD medications. Non-stimulants, such as Strattera and Intuniv, are preferred for the treatment of ADHD symptoms in autistic patients, as stimulant medications (e.g., Ritalin and Adderall) can sometimes make anxiety worse.
Autistic children also have an increased incidence of depression and may require specific medication to treat this aspect of the disorder. Antidepressants like Prozac, Celexa and Zoloft are used most commonly for depression, as well as moderate-to-severe difficulties with anxiety and obsessive-compulsion problems. Melatonin and Clonidine may be used to relieve insomnia.
Outcomes
Predictors of better outcomes include early age at diagnosis, IQ above 50 and acquisition of language by 6 years of age. Most autistic patients will need significant help befriending others, holding down a job and living semi-independently. However, the range of outcomes is broad, from requiring full-time institutional care to living in a more sheltered environment to becoming a fully functional member of society. Each autistic child needs and deserves intensive, personalized therapy, so that he/she can reach his/her maximum potential.
For more information on autism, or to make an appointment with Eric Slosberg, MD, call ProMed Physicians-Pediatrics at (269) 552.2500.